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Old drug, new trick

A Sydney collaboration has reported on a study that suggests that paracetamol, as well as relieving pain, could also be used to prevent conditions associated with free radicals.

15 Mar 2010
A Sydney collaboration hasreported on a study that suggests that paracetamol, as well as relieving pain,could also be used to prevent conditions associated with free radicals (eg,some heart diseases, rheumatoid arthritis and some cancers).

The collaboration involvedthe ARC Centre of Excellence for Free Radical Chemistry and Biotechnology atthe Heart Research Institute, St Vincent's Hospital and The University of NSW,and its report is published in the current edition of Biochemical Pharmacology.

The study reports discovering - in model cell culturesystems using paracetamol doses in the range currently prescribed for painrelief - that paracetamol is able to prevent the enzyme myeloperoxidase from producingthe reactive chemical hypochlorous acid, which (although afactor in the body's natural defence against infection) can damage hearttissue.


Published: 15 Mar 2010